HSBP1
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Official Full Name
heat shock factor binding protein 1 -
Overview
The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes.Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response.During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interactswith the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. -
Synonyms
HSBP1;heat shock factor binding protein 1;heat shock factor-binding protein 1;HSBP1_HUMAN;HSF1BP;Nasopharyngeal carcinoma associated antigen 13;Nasopharyngeal carcinoma-associated antigen 13;NPC A 13;NPC-A-13;NPCA 13
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
HSBP1 involved in several pathways and played different roles in them. We selected most pathways HSBP1 participated on our site, such as Attenuation phase,Cellular response to heat stress,Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cellular response to heat stress | NUP35,DNAJB6,BAG3,HSPA13,HSPA12B,HDAC6,HSBP1B,DNAJC7,NUP50,HSBP1A |
| HSF1-dependent transactivation | HSBP1B,HSBP1A,PTGES3 |
| HSF1 activation | PTGES3,EEF1A1 |
| Cellular responses to stress | TERF1,DNAJC7,POT1,SUZ12B,HSPA12B,KAT5,HSBP1B,ASF1A,AGO3,GABARAPL2 |
| Attenuation phase | HSBP1A,PTGES3,CREBBP,HSBP1B |
Protein Function
HSBP1 has several biochemical functions, for example, protein binding,transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSBP1 itself. We selected most functions HSBP1 had, and list some proteins which have the same functions with HSBP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription corepressor activity | JUB,TBL1X,POU1F1,BHLHE40,NEUROD2,DRAP1,LHX1A,NOC2L,MYBBP1A,HIPK2 |
| protein binding | LETM1,EP400,TPP1,TSC22D1,FAM195B,NR3C1,MOB3C,MPLKIP,AGPAT5,BRAF |
Interacting Protein
HSBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSBP1.
CCDC53;SDCBP;KRTAP10-7;KIAA1217
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References
- Nagashima, Y; Iwata, Y; et al. Exogenous Salicylic Acid Activates Two Signaling Arms of the Unfolded Protein Response in Arabidopsis. PLANT AND CELL PHYSIOLOGY 55:1772-1778(2014).
- Lewis, DJM; Wang, YF; et al. Effect of Vaginal Immunization with HIVgp140 and HSP70 on HIV-1 Replication and Innate and T Cell Adaptive Immunity in Women. JOURNAL OF VIROLOGY 88:11648-11657(2014).
