Recombinant Human HP Protein, MYC/DDK-tagged

• Cat.No.: HP-1891H
• Product Overview: Recombinant human HP protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293

Specification

• Description: This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014].
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 43.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: HP haptoglobin [ Homo sapiens ]
• Official Symbol: HP
• Synonyms: BP; HP2ALPHA2; HPA1S
• Gene ID: 3240
• mRNA Refseq: NM_001126102
• Protein Refseq: NP_001119574
• MIM: 140100
• UniProt ID: P00738

Reviews

07/02/2022

Its superior purity and stability ensure reliable and reproducible results, providing me with confidence in the integrity of my experiments.

01/18/2020

Its impeccable purity and stability ensure accurate and reproducible results, giving me confidence in the reliability of my research outcomes

07/07/2019

Whether I am investigating protein-protein interactions, studying enzymatic activity, or conducting protein structure analyses, the HP protein consistently delivers exceptional performance and accurate results.

Q&As

Can Haptoglobin levels be influenced by genetic factors?

Yes, genetic variations can affect Haptoglobin levels, and understanding these variations can be crucial for personalized medicine approaches.

How does Haptoglobin contribute to the body's defense against oxidative stress?

Haptoglobin acts as an antioxidant by binding to free hemoglobin, preventing the formation of reactive oxygen species that contribute to oxidative stress.

Are there any specific diseases where monitoring Haptoglobin is particularly crucial?

Conditions such as hemolytic anemias, infections, and chronic inflammatory diseases often require monitoring Haptoglobin levels for diagnostic and prognostic purposes.

How is the Haptoglobin test performed in a clinical setting?

The Haptoglobin test is usually conducted through a blood sample, and the serum or plasma is analyzed for Haptoglobin levels.

Can Haptoglobin be a diagnostic marker for conditions other than hemolysis and inflammation?

Yes, altered levels of Haptoglobin are associated with various conditions, including cardiovascular diseases, infections, and certain cancers.