Recombinant Human HNRNPA2B1, MYC/DDK-tagged

• Cat.No.: HNRNPA2B1-37H
• Product Overview: Recombinant Human HNRNPA2B1, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.

Specification

• Description: This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms.
• Source: HEK293 cells
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 35.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 [ Homo sapiens (human) ]
• Official Symbol: HNRNPA2B1
• Synonyms: HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2/B1; HNRPA2B1; heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2 / hnRNP B1; nuclear ribonucleoprotein particle A2 protein; RNPA2; HNRPA2; HNRPB1; SNRPB1; HNRNPA2; HNRNPB1; FLJ22720; DKFZp779B0244
• Gene ID: 3181
• mRNA Refseq: NM_002137
• Protein Refseq: NP_002128
• MIM: 600124
• UniProt ID: P22626
• Chromosome Location: 7p15
• Pathway: Gene Expression; Processing of Capped Intron-Containing Pre-mRNA; mRNA Splicing
• Function: RNA binding; nucleotide binding; poly(A) RNA binding

Reviews

08/29/2022

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12/24/2021

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07/07/2017

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Q&As

How does HNRNPA2B1 contribute to mRNA splicing?

It influences mRNA splicing, affecting transcript diversity.

How do genetic variations in HNRNPA2B1 affect RNA metabolism?

Genetic mutations in HNRNPA2B1 impact RNA splicing and processing.

What is the primary role of HNRNPA2B1 in RNA processing?

HNRNPA2B1 is key for RNA processing and metabolism.

How does HNRNPA2B1 interact with other RNA-binding proteins?

HNRNPA2B1 works with RNA-binding proteins to manage RNA regulation.

What is the impact of altered HNRNPA2B1 activity on neurodegenerative diseases?

Altered HNRNPA2B1 activity is linked to neurodegenerative conditions.

What role does HNRNPA2B1 play in gene regulation?

HNRNPA2B1 regulates gene expression at the RNA level.

What potential therapeutic applications arise from targeting HNRNPA2B1 in RNA-based disorders?

Targeting HNRNPA2B1 could treat RNA processing-related diseases.