Recombinant Human HLA-E Protein, MYC/DDK-tagged

• Cat.No.: HLA-E-1749H
• Product Overview: Recombinant protein of human major histocompatibility complex, class I, E (HLA-E) with a C-Myc/DDK tag was expressed in HEK293T.

Specification

• Description: HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.
• Source: HEK293T
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 37.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Gene Information

• Gene Name: HLA-E major histocompatibility complex, class I, E [ Homo sapiens (human) ]
• Official Symbol: HLA-E
• Synonyms: HLA-E; major histocompatibility complex, class I, E; QA1; HLA-6.2; HLA class I histocompatibility antigen, alpha chain E; MHC class I antigen E; MHC class Ib antigen
• Gene ID: 3133
• mRNA Refseq: NM_005516
• Protein Refseq: NP_005507
• MIM: 143010
• UniProt ID: P13747