Recombinant Human HLA-DOA, GST-tagged

• Cat.No.: HLA-DOA-13814H
• Product Overview: Recombinant Human HLA-DOA protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 25-221a.a.
• Description: HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: HLA-DOA major histocompatibility complex, class II, DO alpha [ Homo sapiens ]
• Official Symbol: HLA-DOA
• Synonyms: HLA-DOA; major histocompatibility complex, class II, DO alpha; HLA DNA, HLA DZA; HLA class II histocompatibility antigen, DO alpha chain; HLA D0 alpha; HLA-D0-alpha; MHC DN-alpha; MHC DZ alpha; lymphocyte antigen; MHC class II antigen DOA; major histocompatibility complex, class II, DN alpha; HLADZ; HLA-DNA; HLA-DZA
• Gene ID: 3111
• mRNA Refseq: NM_002119
• Protein Refseq: NP_002110
• MIM: 142930
• UniProt ID: P06340
• Chromosome Location: 6p21.3
• Pathway: Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem
• Function: MHC class II receptor activity