HLA-DOA

  • Official Full Name

    major histocompatibility complex, class II, DO alpha

  • Overview

    HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.

  • Synonyms

    HLA-DOA;major histocompatibility complex, class II, DO alpha;HLA DNA, HLA DZA;HLA class II histocompatibility antigen, DO alpha chain;HLA D0 alpha;HLA class II histocompatibility antigen, DO alpha chain precursor;HLA DNA;HLA DZA;HLADZ;Lymphocyte antigen;Major histocompatibility complex, class II, DN alpha;MHC class II antigen DOA;MHC DN alpha;MHC DZ alpha;HLA-D0-alpha;MHC DN-alpha;HLA-DNA;HLA-DZA
Cat.# Product name Source (Host) Species Tag Protein Length Price
HLA-DOA-13814H Recombinant Human HLA-DOA, GST-tagged E.coli Human GST 25-221a.a.
HLA-DOA-232H Recombinant Human major histocompatibility complex, class II, DO alpha, His-tagged E.coli Human His 26-217 a.a.
HLA-DOA-4838H Recombinant Human HLA-DOA Protein, GST-tagged Wheat Germ Human GST 28-125 a.a.
HLA-DOA-5502HCL Recombinant Human HLA 293 Cell Lysate HEK293 Human Non

    Involved Pathway

    HLA-DOA involved in several pathways and played different roles in them. We selected most pathways HLA-DOA participated on our site, such as Phagosome,Cell adhesion molecules (CAMs),Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DOA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Intestinal i CD40,IL15RA,IL4,HLA-DMA,TNFRSF17,HLA-DOB,LTBR,CCL25,HLA-DQB1,HLA-DRB3
    Staphylococcus aureus infection SELPLG,DSG1,cgr2b,H2-AA,ICAM1,MBL1,CFH,MBL2,HLA-DRB1,FCGR3
    Type I diabetes mellitus HLA-B,HLA-DRB5,HLA-F,INS2,PTPRN2,GZMB,HLA-DQA1,HSPD1,IFNG,HLA-DOB
    Systemic lupus erythematosus H2-AB1,C1R,ACTN1,HIST2H2AC,HIST1H2BN,GM14476,H2-AA,ACTN3,IFNG,HLA-DQA1
    Cell adhesion molecules (CAMs) HLA-DQA1,CADM1,SDC1,HLA-DMA,CD226,CADM1A,LRRC4,ICAM3,ITGA6B,HLA-DOB
    Tuberculosis MAPK12,IFNA12,FCGR4,IL12A,LAMP1,NFYC,Il23a,FCGR3B,HLA-DQA1,TNFRSF1A
    Toxoplasmosis TYK2,CASP8,GNAO1,BIRC8,LAMC1,GNAI1,GNAI3,PIK3R1,LY96,Casp3
    Phagosome CLEC7A,C1RA,CTSL1B,ATP6AP1B,CALR,ATP6V0CA,HLA-DRB3,ITGB5,TLR4,TLR4BB
    HTLV-I infection NFATC2,LTBR,CD3G,CRTC2,TSPO,RRAS2,XIAP,STAT5A,APC2,WNT5A

    Protein Function

    HLA-DOA has several biochemical functions, for example, MHC class II protein complex binding,MHC class II receptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DOA itself. We selected most functions HLA-DOA had, and list some proteins which have the same functions with HLA-DOA. You can find most of the proteins on our site.

    Function Related Protein
    protein binding SAP30L,CYBA,RAP1GDS1,ITPRIPL1,MUM1,BBS12,P4HA1,HIC1,ASAP1,E2F6
    MHC class II receptor activity HLA-DQA2,HLA-DRA,HLA-DRB4,HLA-DQA1,HLA-DOB,HLA-DQB2,HLA-DRB1,KRT17,HLA-DQB1,HLA-DPA1
    MHC class II protein complex binding HLA-DMB,PKM,HLA-DRA,HLA-DMA,ANXA11,PKM2,HLA-DRB1,ATP1B1,HSP90AA1,HSP90AB1

    Interacting Protein

    HLA-DOA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DOA here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DOA.

    REL

    Resources

    References

    • Yucesoy, B; Johnson, VJ; et al. Genetic Variants in the Major Histocompatibility Complex Class I and Class II Genes Are Associated With Diisocyanate-Induced Asthma. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 56:382-387(2014).
    • Reynolds, RJ; Kelley, JM; et al. Genetic association of htSNPs across the major histocompatibility complex with rheumatoid arthritis in an African-American population. GENES AND IMMUNITY 11:94-97(2010).
    • van Lith, M; van Ham, M; et al. Novel polymorphisms in HLA-DOA and HLA-DOB in B-cell malignancies. IMMUNOGENETICS 54:591-595(2002).

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