Recombinant Human HK2, His-tagged

• Cat.No.: HK2-13807H
• Product Overview: Recombinant Human HK2 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: C-term-350a.a.
• Description: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: HK2 hexokinase 2 [ Homo sapiens ]
• Official Symbol: HK2
• Synonyms: HK2; hexokinase 2; hexokinase-2; HK II; hexokinase type II; hexokinase-2, muscle; muscle form hexokinase; HKII; HXK2; DKFZp686M1669
• Gene ID: 3099
• mRNA Refseq: NM_000189
• Protein Refseq: NP_000180
• MIM: 601125
• UniProt ID: P52789
• Chromosome Location: 2p13
• Pathway: Amino sugar and nucleotide sugar metabolism, organism-specific biosystem; Amino sugar and nucleotide sugar metabolism, conserved biosystem; Butirosin and neomycin biosynthesis, organism-specific biosystem; Butirosin and neomycin biosynthesis, conserved biosystem; Carbohydrate digestion and absorption, organism-specific biosystem; Carbohydrate digestion and absorption, conserved biosystem; Fructose and mannose metabolism, organism-specific biosystem
• Function: ATP binding; glucose binding; hexokinase activity; kinase activity; nucleotide binding; transferase activity