HK2
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Official Full Name
hexokinase 2 -
Overview
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009] -
Synonyms
HK2;hexokinase 2;HKII;HXK2;hexokinase-2;HK II;hexokinase type II;hexokinase-2, muscle;muscle form hexokinase
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- Chicken
- E.coli
- HEK293
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- His
- DDK&Myc
- GST&His
- GST
- Non
- Avi&Fc&His
- Flag
Involved Pathway
HK2 involved in several pathways and played different roles in them. We selected most pathways HK2 participated on our site, such as Glycolysis / Gluconeogenesis,Fructose and mannose metabolism,Galactose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fructose and mannose metabolism | C12orf5,HK1,PFKFB4,FBP1B,TPI1B,TPI1,AKR1B7,AKR1B1,PMM1,ALDOA |
| Starch and sucrose metabolism | GUSB,AMY2A5,UGP2,UGT1AB,HKDC1,GBE1,GBA3,UGT2A1,GYS2,AMY1A |
| Type II diabetes mellitus | TNF,MAPK9,MAPK8,INSR,PKM2,MAFA,PRKCE,SOCS3,MAPK10,SOCS2 |
| Galactose metabolism | PFKMA,PFKMB,GLA,GALK1,UGP2A,Akr1b3,B4GALT2,PGM2,UGP2,GALT |
| Glycolysis / Gluconeogenesis | PFKP,ADH2-1,PDHA1,G6PC3,GAPDHS,ALDH7A1,LDHB,ADH1C,FBP2,ALDOCA |
| Insulin signaling pathway | INS,PRKAR1A,G6PC3,PRKAR2AB,PRKAR1AB,CALML3,RAF1B,SHC3,INSR,IRS1 |
| Central carbon metabolism in cancer | PDHA2,FGFR1,G6PD,TP53,MAP2K2,HRAS,PDHB,SIRT3,NTRK1,SLC7A5 |
| Carbohydrate digestion and absorption | HKDC1,PIK3R1,AMY1A,AKT2,HK1,AMY2A2,SLC2A2,SLC5A1,ATP1A4,SI |
| Amino sugar and nucleotide sugar metabolism | FPGT,NANSA,UGP2B,UGP2A,GPI1,GALE,CHIA.3,HK1,PMM2,GNE |
Protein Function
HK2 has several biochemical functions, for example, ATP binding,fructokinase activity,glucokinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HK2 itself. We selected most functions HK2 had, and list some proteins which have the same functions with HK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glucokinase activity | HK3,HK1,HKDC1 |
| hexokinase activity | HK3,HK1 |
| fructokinase activity | HK3,HKDC1,HK1 |
| ATP binding | SRPK1A,EPB42,KIFC2,HUNK,TNIKA,PNCK,ACACB,STK38L,MST1R,DNA2 |
| mannokinase activity | HKDC1,HK3,HK1 |
| protein binding | SHOX,VPS53,MTF1,ASPSCR1,UBXN1,PRH1,DHX8,CIB3,TEC,HSPD1 |
| glucose binding | SLC2A3,PYGL,G6PDX,HK1,UGP2,HKDC1,G6PD,HK3,SLC2A8,GYS1 |
Interacting Protein
HK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HK2.
UBQLN1;MAGEA12;UBQLN1;ENO1;UBQLN4;HSP90AA1;VCAM1;Tor1aip1;RAD18
Resources
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References
- Yoon, SO; Jeon, TJ; et al. Analysis of the Roles of Glucose Transporter 1 and Hexokinase 2 in the Metabolism of Glucose by Extrahepatic Bile Duct Cancer Cells. CLINICAL NUCLEAR MEDICINE 40:E178-E182(2015).
- Iwamoto, M; Kawada, K; et al. Regulation of F-18-FDG Accumulation in Colorectal Cancer Cells with Mutated KRAS. JOURNAL OF NUCLEAR MEDICINE 55:2038-2044(2014).
