Recombinant Human Histone Deacetylase 2, GST-tagged

• Cat.No.: HDAC2-1590H
• Product Overview: Full-length recombinant human HDAC2 was expressed by baculovirus in Sf9 insect cells using a C-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: HDAC2 or Histone deacetylase 2 belongs to the histone deacetylase family that acts via the formation of large multiprotein complexes, and is responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). HDAC2 forms transcriptional repressor complexes by associating with many different proteins and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
• Applications: HDAC Assay; Western Blot
• Molecular Weight: 92 kDa
• Expression System: Sf9 insect cells using baculovirus
• Form: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
• Purity: >70%
• Concentration: 0.1 ug/ul
• Specific Activity: 4180 RLU/min/ng
• Sequences: Full length
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: Cell cycle; Chronic myeloid leukemia; Direct p53 effectors; Glucocorticoid receptor regulatory network; Hedgehog signaling events mediated by Gli proteins; Hemostasis; Huntington"s disease; Notch signaling pathway; Pathways in cancer; Regulation of Telomerase; Signaling events mediated by HDAC Class I; Signalling by NGF; TNF-alpha/NF-kB Signaling Pathway; p75 NTR receptor-mediated signaling; p75NTR negatively regulates cell cycle via SC1

Gene Information

• Gene Name: HDAC2 histone deacetylase 2 [ Homo sapiens ]
• Official Symbol: HDAC2
• Synonyms: HDAC2; histone deacetylase 2; HD2; RPD3; YAF1; histone deacetylase 2; OTTHUMP00000017046; OTTHUMP00000227077; OTTHUMP00000227078; YY1-associated factor 1; transcriptional regulator homolog RPD3
• Gene ID: 3066
• mRNA Refseq: NM_001527
• Protein Refseq: NP_001518
• MIM: 605164
• UniProt ID: Q92769
• Chromosome Location: 6q21
• Function: NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; histone deacetylase activity (H3-K16 specific); hydrolase activity; transcription factor binding; chromatin binding; enzyme binding; protein deacetylase activity; protein deacetylase activity; sequence-specific DNA binding