Active Recombinant Human HDAC2, His-tagged

• Cat.No.: HDAC2-28263TH
• Product Overview: Recombinant Human HDAC2, a single, non-glycosylated polypeptide chain fussed with His tag was expressed in Sf9 insect cells.

Specification

• Description: HDAC2 is a member of the histone deacetylase family that performs through the construction of large multiprotein complexes and are in charge of the deacetylation of lysine residues on the N-terminal region of the core histones. HDAC2 forms transcriptional repressor complexes by relating to a diversity of proteins, like YY1- a mammalian zinc-finger transcription factor. Additionally, HDAC2 has a vital part in transcriptional regulation, cell cycle progression and developmental procedures.
• Source: Insect cells
• Species: Human
• Tag: His
• Form: The HDAC2 solution contains 20 mM Tris-HCl buffer (pH 8.0), 300 mM NaCl and 20% Glycerol. Frozen solution.
• Bio-activity: > 500 pmol/min/μg
• Molecular Mass: 56.2 kDa, observed by reducing SDS-PAGE.
• AA Sequence: MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTHNLLLNYGLYR KMEIYRPHKA TAEEMTKYHS DEYIKFLRSIRPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVAGAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLAILELLKYHQR VLYIDIDIHH GDGVEEAFYT TDRVMTVSFHKYGEYFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQIFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVKGHAKCVEVVK TFNLPLLMLG GGGYTIRNVA RCWTYETAVALDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYMEKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGEDPDKRISIRA SDKRIACDEE FSDSEDEGEG GRRNVADHKKGAKKARIEED KKETEDKKTD VKEEDKSKDN SGEKTDTKGTKSEQLSNPGH HHHHH
• Endotoxin: < 1 EU/μg, determined by LAL method.
• Purity: > 80% by SDS-PAGE analysis.
• Usage: For research use only
• Storage: HDAC2 remains stable up to 6 months at -80? from date of receipt. For maximum recovery of product, centrifuge original vial prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: HDAC2 histone deacetylase 2 [ Homo sapiens ]
• Official Symbol: HDAC2
• Synonyms: HD2; RPD3; YAF1; histone deacetylase 2; YY1-associated factor 1; transcriptional regulator homolog RPD3
• Gene ID: 3066
• mRNA Refseq: NM_001527
• Protein Refseq: NP_001518
• MIM: 605164
• UniProt ID: Q92769
• Chromosome Location: 6q21
• Pathway: Alcoholism, organism-specific biosystem; Alcoholism, conserved biosystem; Cell cycle, organism-specific biosystem
• Function: Krueppel-associated box domain binding; NF-kappaB binding; core promoter binding