Recombinant Human Hemopoietic Cell Kinase, GST-tagged, Active

• Cat.No.: HCK-327H
• Product Overview: Recombinant human HCK (230-497) was expressed by baculovirus inSf9 cellsusing an N-terminal GST tag. MW=57kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 230-497 a.a.
• Description: HCK, a protein-tyrosine kinase belonging to the Src family, is expressed in certain hemopoietic cells and especially prominent in cells of myeloid lineage, particularly mature granulocytes and monocytes. HCK gene is located on chromosome sequence 20q11-q12, a region that is affected by interstitial deletions in some acute myeloid leukemias and myeloproliferative disorders suggesting damage to HCK may contribute to the pathogenesis of these conditions.
• Sequence: 230-497.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: HCK hemopoietic cell kinase [ Homo sapiens ]
• Synonyms: HCK; hemopoietic cell kinase; JTK9; Tyrosine-protein kinase HCK; EC 2.7.10.2; Hemopoietic cell kinase; p59-HCK/p60-HCK
• Gene ID: 3055
• mRNA Refseq: NM_002110
• Protein Refseq: NP_002101
• UniProt ID: P08631
• Chromosome Location: 20q11-q12
• MIM: 142370
• Pathway: Chemokine signaling pathway; Fc gamma R-mediated phagocytosis; HIV Infection
• Function: ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; transferase activity