HCK
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Official Full Name
hemopoietic cell kinase -
Overview
Hck is a member of the Src family of non-receptor tyrosine kinases involved in the modulation of a wide variety of normal and pathogenic cellular processes including growth, development, differentiation, and carcinogenesis. These proteins contain a consen -
Synonyms
HCK;hemopoietic cell kinase;tyrosine-protein kinase HCK;JTK9;p59-HCK/p60-HCK;hematopoietic cell kinase;p59Hck;p61Hck
Recombinant Proteins
- Human
- Rat
- Mouse
- Sf9 Cells
- Insect Cells
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- GST&His
- His&T7
- Non
- DDK&Myc
- Avi&Fc&His
Involved Pathway
HCK involved in several pathways and played different roles in them. We selected most pathways HCK participated on our site, such as Chemokine signaling pathway,Fc gamma R-mediated phagocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HCK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fc gamma R-mediated phagocytosis | cgr2b,PAK1,AMPH,SCIN,ASAP3,PIK3CB,PLA2G6,FCGR1,WASF1,PLA2G4A |
| Chemokine signaling pathway | CCR1L1,CXCL12,CCR5,Ccl21c,PARD3,CXCR5,MAPK3,XCR1,Ccl21a,GNG5 |
Protein Function
HCK has several biochemical functions, for example, ATP binding,non-membrane spanning protein tyrosine kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HCK itself. We selected most functions HCK had, and list some proteins which have the same functions with HCK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SIAH1,MAP2K5,MRPL11,NBR1,GPANK1,EFHC2,NINJ2,PKN2,KRTAP12-2,HGF |
| protein tyrosine kinase activity | FGR,BCR,KDR,TYRO3,MAP2K7,FYNA,TEK,TESK2,SRMS,BMX |
| receptor binding | MLYCD,CSK,RAB8B,ENSA,ADCYAP1,NPFF,CNPY4,PARK7,IL28A,REN |
| non-membrane spanning protein tyrosine kinase activity | BLK,TYK2,PKDCC,JAK2A,FER,BTK,JAK1,SRC,WEE2,ITK |
| ATP binding | PRKG2,UBE2M,MARS,RLN1,UBE2E3,APAF1,PRKG1,AACS,MYO6A,EIF4A1A |
Interacting Protein
HCK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HCK here. Most of them are supplied by our site. Hope this information will be useful for your research of HCK.
KHDRBS1;polg_hcvh;WAS;SOS1
Resources
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References
- Stegeman, H; Kaanders, JHAM; et al. Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines. MOLECULAR CANCER 12:-(2013).
- Ben-Zimra, M; Bachelet, I; et al. Eosinophil major basic protein activates human cord blood mast cells primed with fibroblast membranes by integrin-beta 1. ALLERGY 68:1259-1268(2013).
