Recombinant Human HBA2

• Cat.No.: HBA2-29306TH
• Product Overview: Recombinant full length Human Hemoglobin subunit alpha expressed in Saccharomyces cerevisiae; amino acids 1-142 , MWt 15.2kDa. Protein is tagged with 26 kDa proprietary tag.

Specification

• Species: Human
• Tag: Non
• Protein Length: 1-142 a.a.
• Description: The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5 untranslated regions and the introns, but they differ significantly over the 3 untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 30% Glycerol, 0.5% Triton-X-100, 50mM HEPES, 30mM Glutathione, 100mM Sodium chloride, 1mM DTT, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequences of amino acids: MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTT KTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMP NALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPA EFTPAVHASLDKFLASVSTVLTSKYR
• Full Length: Full L.

Gene Information

• Gene Name: HBA2 hemoglobin, alpha 2 [ Homo sapiens ]
• Official Symbol: HBA2
• Synonyms: HBA2; hemoglobin, alpha 2; hemoglobin subunit alpha
• Gene ID: 3040
• mRNA Refseq: NM_000517
• Protein Refseq: NP_000508
• MIM: 141850
• Uniprot ID: P69905
• Chromosome Location: 16p13.3
• Pathway: African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Malaria, organism-specific biosystem; Malaria, conserved biosystem; Selenium Pathway, organism-specific biosystem
• Function: contributes_to haptoglobin binding; heme binding; metal ion binding; oxygen binding; oxygen transporter activity