Recombinant Human HAAO, GST-tagged

• Cat.No.: HAAO-13653H
• Product Overview: Recombinant Human HAAO protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 1-286a.a.
• Description: 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: HAAO 3-hydroxyanthranilate 3,4-dioxygenase [ Homo sapiens ]
• Official Symbol: HAAO
• Synonyms: HAAO; 3-hydroxyanthranilate 3,4-dioxygenase; HAD; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase; HAO; 3-HAO
• Gene ID: 23498
• mRNA Refseq: NM_012205
• Protein Refseq: NP_036337
• MIM: 604521
• UniProt ID: P46952
• Chromosome Location: 2p
• Pathway: Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; NAD biosynthesis II (from tryptophan), organism-specific biosystem; NAD biosynthesis II (from tryptophan), conserved biosystem; Tryptophan catabolism, organism-specific biosystem; Tryptophan metabolism, organism-specific biosystem
• Function: 3-hydroxyanthranilate 3,4-dioxygenase activity; 3-hydroxyanthranilate 3,4-dioxygenase activity; electron carrier activity; ferrous iron binding; metal ion binding; oxidoreductase activity; oxygen binding