Recombinant Human Guanylate Cyclase 1, Soluble, Alpha 3, His-tagged

• Cat.No.: GUCY1A3-627H
• Product Overview: Recombinant Human Guanylate Cyclase 1, Soluble, Alpha 3 is produced inSf9 cellsfused at the C-terminus to a His-tag. MW= 70kDa-86kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: His
• Description: Guanylate cyclase soluble subunit alpha-3 is an enzyme that in humans is encoded by the GUCY1A3 gene. Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.
• Purity: ≥90% (SDS-PAGE).
• Concentration: 0.4mg/ml.
• Formulation: Liquid. In 40mM TEA, pH 7.4 containing 2mM DTT, 1mM MgCl2 and 30% glycerol.
• Application: Biophysical and enzymatic studies and drug screening.
• Specificity: ≥0.075µmol/mg/min.
• Storage And Stability: -80°C. We do not recommend to store for longer periods after opening and thawing of the product. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: GUCY1A3 guanylate cyclase 1, soluble, alpha 3 [ Homo sapiens ]
• Synonyms: GUCY1A3; guanylate cyclase 1, soluble, alpha 3; GUCA3; GC-SA3; GUC1A3; GUCSA3; GUCY1A1; guanylate cyclase soluble subunit alpha-3; GCS-alpha-1; GCS-alpha-3; GC-S-alpha-1; soluble guanylate cyclase large subunit; EC 4.6.1.2
• Gene ID: 2982
• mRNA Refseq: NM_000856
• Protein Refseq: NP_000847
• MIM: 139396
• UniProt ID: Q02108
• Chromosome Location: 4q31.3-q33; 4q31.1-q31.2
• Pathway: Gap junction; Long-term depression; Purine metabolism; Vascular smooth muscle contraction
• Function: GTP binding; guanylate cyclase activity; heme binding; ion binding; nucleotide binding; protein heterodimerization activity; receptor activity