Recombinant Human Growth Arrest-specific 7, His-tagged

• Cat.No.: GAS7-507H
• Product Overview: Recombinant Human GAS7 fused to His-tag at N-terminus, was expressed inE.coliand purified by conventional chromatography techniques. MW=49.8kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Growth arrest-specific 7, also known as GAS7, is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development by promoting maturation and morphological differentiation of cerebellar neurons. Inhibition of GAS7 production in terminally differentiating cultures of embryonic murine cerebellum impedes neurite outgrowth. The hyper-expression of GAS7 may play an important role in the initiation and development of human osteosarcoma.
• Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MKPGMVPPPP GEESQTVILP PGWQSYLSPQ GRRYYVNTTT NETTWERPSS SPGIPASPGS HRSSLPPTVN GYHASGTPAH PPETAHMSVR KSTGDSQNLG SSSPSKKQSK ENTITINCVT FPHPDTMPEQ QLLKPTEWSY CDYFWADKKD PQGNGTVAGF ELLLQKQLKG KQMQKEMSEF IRERIKIEED YAKNLAKLSQ NSLASQEEGS LGEAWAQVKK SLADEAEVHL KFSAKLHSEV EKPLMNFREN FKKDMKKCDH HIADLRKQLA SRYASVEKAR KALTERQRDL EMKTQQLEIK LSNKTEEDIK KARRKSTQAG DDLMRCVDLY NQAQSKWFEE MVTTTLELER LEVERVEMIR QHLCQYTQLR HETDMFNQST VEPVDQLLRK VDPAKDRELW VREHKTGNIR PVDMEI.
• From: Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 100mM NaCl, 2mM DTT, 10% glycerol.
• Purity: > 95% by SDS–PAGE.
• Concentration: 1mg/ml (determined by Bradford assay).
• Endotoxin Level: <1.0 EU per 1μg of protein (determined by LAL method).
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: GAS7 growth arrest-specific 7 [ Homo sapiens ]
• Synonyms: GAS7; growth arrest-specific 7; MGC1348; KIAA0394; MLL/GAS7;Growth arrest-specific protein 7;GAS-7;MLL/GAS7 fusion protein
• Gene ID: 8522
• mRNA Refseq: NM_001130831
• Protein Refseq: NP_001124303
• MIM: 603127
• UniProt ID: O60861
• Chromosome Location: 17p13.1
• Function: actin filament binding;protein binding;transcription factor activity