Recombinant Human GRHPR, His-tagged

• Cat.No.: GRHPR-28538TH
• Product Overview: Recombinant full length Human GRHPR with N terminal His tag; amino acids 1-328 , 37.8kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 328 amino acids
• Description: This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene.
• Conjugation: HIS
• Molecular Weight: 37.800kDa inclusive of tags
• Tissue specificity: Ubiquitous. Most abundantly expressed in the liver.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 0.2M Sodium chloride, 5mM DTT, 20mM Tris HCl, pH 8.0
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MRPVRLMKVF VTRRIPAEGR VALARAADCE VEQWDSDEPI PAKELERGVA GAHGLLCLLS DHVDKRILDA AGANLKVIST MSVGIDHLAL DEIKKRGIRV GYTPDVLTDT TAELAVSLLL TTCRRLPEAI EEVKNGGWTS WKPLWLCGYG LTQSTVGIIG LGRIGQAIAR RLKPFGVQRF LYTGRQPRPE EAAEFQAEFV STPELAAQSD FIVVACSLTP ATEGLCNKDF FQKMKETAVF INISRGDVVN QDDLYQALAS GKIAAAGLDV TSPEPLPTNH PLLTLKNCVI LPHIGSATHR TRNTMSLLAA NNLLAGLRGE PMPSELKL
• Sequence Similarities: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Gene Information

• Gene Name: GRHPR glyoxylate reductase/hydroxypyruvate reductase [ Homo sapiens ]
• Official Symbol: GRHPR
• Synonyms: GRHPR; glyoxylate reductase/hydroxypyruvate reductase; GLXR; PH2; primary hyperoxaluria type 2
• Gene ID: 9380
• mRNA Refseq: NM_012203
• Protein Refseq: NP_036335
• MIM: 604296
• Uniprot ID: Q9UBQ7
• Chromosome Location: 9q12
• Pathway: Glyoxylate and dicarboxylate metabolism, organism-specific biosystem; Glyoxylate and dicarboxylate metabolism, conserved biosystem; Glyoxylate metabolism, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem
• Function: NAD binding; cofactor binding; glycerate dehydrogenase activity; glyoxylate reductase (NADP) activity; glyoxylate reductase (NADP) activity