GRHPR
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Official Full Name
glyoxylate reductase/hydroxypyruvate reductase -
Overview
This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. -
Synonyms
GRHPR;glyoxylate reductase/hydroxypyruvate reductase;GLXR;PH2;primary hyperoxaluria type 2;glycerate 2 dehydrogenase;GLYD;GRHPR_HUMAN;OTTHUMP00000021379;OTTHUMP00000021380;OTTHUMP00000046131;PH 2;glycerate-2-dehydrogenase
Recombinant Proteins
- Human
- Mouse
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His&SUMO
- His
- Non
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GRHPR-13526H | Recombinant Human GRHPR, GST-tagged | E.coli | Human | GST | 100-328a.a. | |
| Grhpr-1231M | Recombinant Mouse Grhpr Protein, His-SUMO-tagged | E.coli | Mouse | His&SUMO | 1-328 a.a. |
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| GRHPR-2491H | Recombinant Human GRHPR, His-tagged | E.coli | Human | His |
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| GRHPR-28536TH | Recombinant Human GRHPR, His-tagged | Human | His | 328 amino acids |
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| GRHPR-28538TH | Recombinant Human GRHPR, His-tagged | E.coli | Human | His | 328 amino acids |
|
| GRHPR-5749HCL | Recombinant Human GRHPR 293 Cell Lysate | HEK293 | Human | Non |
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| GRHPR-2502H | Recombinant Human GRHPR Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| Grhpr-3307M | Recombinant Mouse Grhpr Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| GRHPR-5329H | Recombinant Human GRHPR Protein, GST-tagged | Wheat Germ | Human | GST |
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| GRHPR-5619HF | Recombinant Full Length Human GRHPR Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 328 amino acids |
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Involved Pathway
GRHPR involved in several pathways and played different roles in them. We selected most pathways GRHPR participated on our site, such as Glycine, serine and threonine metabolism,Pyruvate metabolism,Glyoxylate and dicarboxylate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRHPR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pyruvate metabolism | LDHB,PDHB,ALDH9A1B,SLC16A8,LDHC,PDHA1,PC,LDHBA,ALDH3A2A,PDK2 |
| Metabolic pathways | DGAT2,SEPHS1,GALNTL2,ALPI.1,COQ2,PIK3C3,POLR2EB,COASY,NDUFS4,UGT2A3 |
| Glycine, serine and threonine metabolism | SARDH,ALDH7A1,GCSHB,MAOA,GCSHA,PGAM1A,CTH,SHMT2,SRR,DLDH |
| Glyoxylate and dicarboxylate metabolism | GLULB,HAO1,PCCB,ACAT1,GLUL,GLYCTK,ACO1,SHMT1,GRHPRB,GCSH |
Protein Function
GRHPR has several biochemical functions, for example, NAD binding,NADPH binding,carboxylic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRHPR itself. We selected most functions GRHPR had, and list some proteins which have the same functions with GRHPR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hydroxypyruvate reductase activity | GRHPRB,GRHPRA |
| carboxylic acid binding | PCK1,AKR1C2,HMGCL,AKR1C21,HIF1AN,GOT1 |
| glyoxylate reductase (NADP) activity | GRHPRA,GRHPRB |
| NAD binding | TESCA,HIBADHA,IDH3B,PARP1,NDUFV1,HSD3B5,ME3,GAPDH,AOX3,HSD3B4 |
| protein homodimerization activity | PDCD10,TRIM8,LRRC41,CRYBB2,MAP3K13,TERF2,NFKB1,IL6R,SLC22A6,MYO7A |
| NADPH binding | TP53I3,MTRR,KCNAB1,DHFR,DECR1,HMGCR,CBR3,QDPR,CRYZ,CBR4 |
Interacting Protein
GRHPR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRHPR here. Most of them are supplied by our site. Hope this information will be useful for your research of GRHPR.
CDC7;LSM1;FOS;PTH2R;GLS2
Resources
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References
- Takayama, T; Takaoka, N; et al. Ethnic differences in GRHPR mutations in patients with primary hyperoxaluria type 2. CLINICAL GENETICS 86:342-348(2014).
- Naderi, G; Latif, A; et al. Failure of isolated kidney transplantation in a pediatric patient with primary hyperoxaluria type 2. PEDIATRIC TRANSPLANTATION 18:E69-E73(2014).
