Recombinant Human Gremlin 2, His-tagged

• Cat.No.: GREM2-2614H
• Product Overview: Recombinant human Gremlin-2 is a N-terminus His-tagged protein that was expressed fromE. coli.MW = 17.2 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Gremlin (also known as Increased in High Glucose Protein 2, IHG-2, Down-regulated in Mostransformed cells protein, Drm) functions as a bone morphogenetic protein (BMP) antagonist. It acts by binding to, and forming heterodimers with BMP-2, BMP-4, BMP-7, thus preventing them from interacting with their cell surface receptors.
• Purity: >95% by SDS-PAGE and HPLC analyses. Endotoxin level is <0.1 ng per μg of Gremlin-2.
• Form: Lyophilized with no additives.
• Reconstitution: Centrifuge the vial prior to opening. Reconstitute to 1 mg/ml with sterilized dH2O. Pipette to dissolve the protein pellet completely.
• Storage: The lyophilized protein is best-stored desiccated below 0℃. Reconstituted protein should be stored at working aliquots at -20℃. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: GREM2 gremlin 2 [ Homo sapiens ]
• Synonyms: GREM2; gremlin 2; PRDC; DAND3; CKTSF1B2; gremlin-2; DAN domain family member 3; protein related to DAN and Cerberus; cysteine knot superfamily 1, BMP antagonist 2; gremlin 2, cysteine knot superfamily, homolog; gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis)
• Gene ID: 64388
• mRNA Refseq: NM_022469
• Protein Refseq: NP_071914
• MIM: 608832
• UniProt ID: Q9H772
• Chromosome Location: 1q43
• Pathway: Signaling by BMP
• Function: cytokine activity