Recombinant Human GRB2-associated Binding Protein 1, His-tagged

• Cat.No.: GAB1-1450H
• Product Overview: Recombinant full-length human GAB1 was expressed by baculovirus inSf9insect cells using an N-terminal His tag. MW = 108 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: His
• Description: GAB1 is a member of the IRS1-like multisubstrate docking protein family and is a direct substrate of the epidermal growth factor receptor and the insulin receptor. GAB1 is tyrosine phosphorylated upon stimulation of cells with various cytokines, growth factors, and antigen receptor. Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains such as SHP2 and phosphatidylinositol 3-kinase. GAB1 is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis.
• Sequence: Full length.
• Applications: Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: GAB1 GRB2-associated binding protein 1 [ Homo sapiens ]
• Synonyms: GAB1; GRB2-associated binding protein 1; GRB2-associated-binding protein 1; Growth factor receptor bound protein 2-associated protein 1; GRB2-associated binder 1; GRB2-associated binder 1
• Gene ID: 2549
• mRNA Refseq: NM_002039
• Protein Refseq: NP_002030
• MIM: 604439
• UniProt ID: Q13480
• Chromosome Location: 4q31.21
• Pathway: ErbB signaling pathway; Neurotrophin signaling pathway; Renal cell carcinoma
• Function: SH3/SH2 adaptor activity; protein binding