GAB1
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Official Full Name
GAB1 GRB2-associated binding protein 1 -
Synonyms
GAB1;GRB2-associated binding protein 1;GRB2-associated-binding protein 1;GRB2-associated binder 1;growth factor receptor bound protein 2-associated protein 1
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cells
- Sf9 Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His&T7
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
GAB1 involved in several pathways and played different roles in them. We selected most pathways GAB1 participated on our site, such as ErbB signaling pathway,Ras signaling pathway,Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bacterial invasion of epithelial cells | SEPT6,CLTC,WASF1,PIK3CG,ILK,CBL,CDC42,SEPT9,VCL,CRKL |
| Neurotrophin signaling pathway | MAP2K2,RPS6KA2,NGFR,MAGED1,RAF1,PSEN1,ABL1,BCL2,RPS6KA3,NTRK2 |
| Proteoglycans in cancer | PDPK1,NRAS,PRKCB,CAV3,MTOR,ANK2,CD63,FZD5,WNT2,PTCH1 |
| ErbB signaling pathway | EGFRA,PAK2B,MAPK3,MAP2K4,ERBB2,PAK1,GSK3B,PRKCG,ABL2,MAP2K2B |
| Ras signaling pathway | RASA4,PRKCA,PLA2G12A,GRIN2A,FGF10,RASGRP3,RASSF1,RASA3,MET,RAF1 |
| Phospholipase D signaling pathway | PIK3CD,PIP5K1C,SHC1,FYN,NRAS,PDGFC,GNA12,INS2,GRM4,GRM8 |
| Renal cell carcinoma | AHA-1,KRAS,GRB2,RBX1,ARAF,FH,ETS1,RAF1,SOS1,NRAS |
Protein Function
GAB1 has several biochemical functions, for example, SH3/SH2 adaptor activity,protein binding,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GAB1 itself. We selected most functions GAB1 had, and list some proteins which have the same functions with GAB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| signal transducer activity | GPR149,CELSR3,OLFR147,GJA1,HCAR1-2,GPR158,VMN1R52,OLFR480,AVPR2L,CCR9A |
| protein binding | SLC16A3,USF2,ELP4,NUP107,SREK1,CTBP2,TMEM185A,POLR1A,AIRE,CSTF2T |
| SH3/SH2 adaptor activity | SKAP1,NCK1,SH3BGR,LAT,ITSN2,SH2D3C,PTPN11,STAM,CHN1,SH2D1A |
Interacting Protein
GAB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GAB1.
PTPN11
GAB1 Related Signal Pathway
Resources
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References
- Pennacchietti, S; Cazzanti, M; et al. Microenvironment-Derived HGF Overcomes Genetically Determined Sensitivity to Anti-MET Drugs. CANCER RESEARCH 74:6598-6609(2014).
- Takeuchi, S; Wang, W; et al. Dual Inhibition of Met Kinase and Angiogenesis to Overcome HGF-Induced EGFR-TKI Resistance in EGFR Mutant Lung Cancer. AMERICAN JOURNAL OF PATHOLOGY 181:1034-1043(2012).
