Recombinant Human GRB14, His-tagged

• Cat.No.: GRB14-13519H
• Product Overview: Recombinant Human GRB14 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 225-540a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: GRB14 growth factor receptor-bound protein 14 [ Homo sapiens ]
• Official Symbol: GRB14
• Synonyms: GRB14; growth factor receptor-bound protein 14; GRB14 adapter protein
• Gene ID: 2888
• mRNA Refseq: NM_004490
• Protein Refseq: NP_004481
• MIM: 601524
• UniProt ID: Q14449
• Chromosome Location: 2q22-q24
• Pathway: Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Hemostasis, organism-specific biosystem; Insulin Pathway, organism-specific biosystem; Insulin Signaling, organism-specific biosystem; Tie2 Signaling, organism-specific biosystem
• Function: SH3/SH2 adaptor activity; phosphoprotein binding