Recombinant Human GPX4 Protein

• Cat.No.: GPX4-5311H
• Product Overview: Human GPX4 (P36969, 25 a.a. - 197 a.a.) U73C mutant partial recombinant protein expressed in Escherichia coli.

Specification

• Description: Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, experimental evidence for alternative splicing exists; alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. [provided by RefSeq
• Source: E. coli
• Species: Human
• Form: Lyophilized
• Molecular Mass: 19 kDa
• Purity: > 95% by SDS-PAGE
• Applications: SDS-PAGE
• Storage: Store at -20 centigrade. After reconstitution, store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: Lyophilized from 20 mM Hepes, pH 7.4
• Tag: Non
• Protein length: 25-197 a.a.

Gene Information

• Gene Name: GPX4 glutathione peroxidase 4 [ Homo sapiens ]
• Official Symbol: GPX4
• Synonyms: GPX4; glutathione peroxidase 4; glutathione peroxidase 4 (phospholipid hydroperoxidase); phospholipid hydroperoxide glutathione peroxidase, mitochondrial; MCSP; PHGPx; phospholipid hydroperoxidase; sperm nucleus glutathione peroxidase; GPx-4; snGPx; GSHPx-4; snPHGPx
• Gene ID: 2879
• mRNA Refseq: NM_001039847
• Protein Refseq: NP_001034936
• MIM: 138322
• UniProt ID: P36969