GPX4
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Official Full Name
glutathione peroxidase 4 -
Overview
This gene encodes a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. The encoded protein has been identified as a moonlighting protein based on its ability to serve dual functions as a peroxidase as well as a structural protein in mature spermatozoa. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] -
Synonyms
GPX4;glutathione peroxidase 4;MCSP;GPx-4;PHGPx;snGPx;GSHPx-4;snPHGPx;phospholipid hydroperoxide glutathione peroxidase, mitochondrial;phospholipid hydroperoxidase;sperm nucleus glutathione peroxidase
Recombinant Proteins
- Human
- Rat
- Mouse
- Pongo Pygmaeus
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- Flag
- Non
- His&GST
- His&T7
- His&SUMO
- His&Fc&Avi
Involved Pathway
GPX4 involved in several pathways and played different roles in them. We selected most pathways GPX4 participated on our site, such as Glutathione metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutathione metabolism | GSTM3,GSTM1,GPX3,GGT1A,GGCTB,GGT1,GCLM,GSTT1,GPX1A,GGT5A |
Protein Function
GPX4 has several biochemical functions, for example, glutathione peroxidase activity,phospholipid-hydroperoxide glutathione peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPX4 itself. We selected most functions GPX4 had, and list some proteins which have the same functions with GPX4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phospholipid-hydroperoxide glutathione peroxidase activity | GPX1 |
| glutathione peroxidase activity | GPX4B,PRDX6,MGST2,GSTT1,GPX4A,GPX1A,MGST3,CLIC2,GPX1,GPX3 |
Interacting Protein
GPX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPX4.
OTUD5;MAPK13;PRDX6
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