Recombinant Human Golgi associated PDZ and coiled-coil motif containing, His-tagged

• Cat.No.: GOPC-1941H
• Product Overview: Recombinant human GOPC protein fused to his-tag was expressed inE.coliand purified by using conventional chromatography techniques. 21.5 kDa (198aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: GOPC, also known as PIST, is a PDZ domain-containing Golgi protein. This protein functions as a homooligomer that interacts with a variety of proteins and plays a role in intracellular protein trafficking and degradation. Additionally, GOPC is thought to regulate ionic currents via membrane channel modification and may also play a role in autophagy. Chromosomal aberrations in the gene encoding GOPC are found in glioblastoma multiform (GBM), a common and aggressive form of brain tumor, suggesting a role for mutated PIST in carcinogenesis.
• Purity: > 90% by SDS – PAGE.
• Physical Appearance: Liquid.
• Formulation: In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol 1mM DTT.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MIRKVLLLKE DHEGLGISIT GGK EHGVPIL ISEIHPGQPA DRCGGLHVGD AILAVNGVNL RDTKHKEAVT ILSQ QRGEIE FEVVYVAPEV DSDDENVEYE DESGHRYRLY LDEL EGGGNP GASCKDTSGE IKVLQGFNKK AVTDTHENGD LGTASETPLD DGASKLDDLH TLYHKKSY.
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: GOPC golgi-associated PDZ and coiled-coil motif containing [ Homo sapiens ]
• Synonyms: GOPC; golgi associated PDZ and coiled-coil motif containing; CAL; FIG; PIST; GOPC1; AI844555; 2210402P09Rik; PDZ domain-containing protein PIST; PDZ protein interacting specifically with TC10; golgi-associated PDZ and coiled-coil motif-containing protein; dJ94G16.2; Fused in glioblastoma; CFTR-associated ligand; Golgi associated PDZ and coiled-coil motif containing protein; PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10.
• Gene ID: 57120
• mRNA Refseq: NM_001017408
• Protein Refseq: NP_001017408
• MIM: 606845
• UniProt ID: Q9HD26
• Chromosome Location: 6q21
• Function: cystic fibrosis transmembrane conductance regulator binding; protein binding; small GTPase regulator activity