Recombinant Human GNB4, GST-tagged

• Cat.No.: GNB4-13357H
• Product Overview: Recombinant Human GNB4 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimers disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-340a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 [ Homo sapiens ]
• Official Symbol: GNB4
• Synonyms: GNB4; guanine nucleotide binding protein (G protein), beta polypeptide 4; guanine nucleotide-binding protein subunit beta-4; transducin beta chain 4; G protein beta-4 subunit; guanine nucleotide binding protein beta subunit 4
• Gene ID: 59345
• mRNA Refseq: NM_021629
• Protein Refseq: NP_067642
• MIM: 610863
• UniProt ID: Q9HAV0
• Chromosome Location: 3q27.1
• Pathway: ADP signalling through P2Y purinoceptor 1, organism-specific biosystem; ADP signalling through P2Y purinoceptor 12, organism-specific biosystem; Activation of Kainate Receptors upon glutamate binding, organism-specific biosystem; Aquaporin-mediated transport, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem
• Function: signal transducer activity