Recombinant Human Glycerol-3-Phosphate Dehydrogenase 1-Like, His-tagged

• Cat.No.: GPD1L-6866H
• Product Overview: Recombinant human GPD1L protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography. MW: 40.6 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-351aa
• Description: GPD1L converts sn-glycerol 3-phosphate to glycerone phosphate. This protein is found in the cytoplasm, associated with the plasma membrane, where it binds the sodium channel, voltage-gated, type V, alpha subunit (SCN5A). Mutations in GPD1L are the cause of sudden infant death syndrome (SIDS) and Brugada syndrome type 2, an autosomal dominant tachyarrhythmia.
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 1mM DTT.
• Molecular Mass: 40.6 kDa (371aa), confirmed by MALDI-TOF.
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MAAAPLKVCI VGSGNWGSAV AKIIGNNVKK LQKFASTVKM WVFEETVNGR KLTDIINNDH ENVKYLPGHK LPENVVAMSN LSEAVQDADL LVFVIPHQFI HRICDEITGR VPKKALGITL IKGIDEGPEG LKLISDIIRE KMGIDISVLM GANIANEVAA EKFCETTIGS KVMENGLLFK ELLQTPNFRI TVVDDADTVE LCGALKNIVA VGAGFCDGLR CGDNTKAAVI RLGLMEMIAF ARIFCKGQVS TATFLESCGV ADLITTCYGG RNRRVAEAFA RTGKTIEELE KEMLNGQKLQ GPQTSAEVYR ILKQKGLLDK FPLFTAVYQI CYESRPVQEM LSCLQSHPEH T
• Purity: >95% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: GPD1L glycerol-3-phosphate dehydrogenase 1-like [ Homo sapiens ]
• Official Symbol: GPD1L
• Synonyms: GPD1L; glycerol-3-phosphate dehydrogenase 1-like; glycerol-3-phosphate dehydrogenase 1-like protein; KIAA0089; GPD1-L
• Gene ID: 23171
• mRNA Refseq: NM_015141
• Protein Refseq: NP_055956
• MIM: 611778
• UniProt ID: Q8N335
• Chromosome Location: 3p22.3
• Pathway: Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Glycerophospholipid metabolism, organism-specific biosystem; Glycerophospholipid metabolism, conserved biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Triglyceride Biosynthesis, organism-specific biosystem
• Function: NAD binding; glycerol-3-phosphate dehydrogenase [NAD+] activity; protein homodimerization activity