Recombinant Human GPD1L, His-tagged

• Cat.No.: GPD1L-28584TH
• Product Overview: Recombinant full-length Human GPD1L with a N terminal His tag. 371 amino acids with a predicted MWt 40.6 kDa including tag.

Specification

• Description: The protein encoded by this gene catalyzes the conversion of sn-glycerol 3-phosphate to glycerone phosphate. The encoded protein is found in the cytoplasm, associated with the plasma membrane, where it binds the sodium channel, voltage-gated, type V, alpha subunit (SCN5A). Defects in this gene are a cause of Brugada syndrome type 2 (BRS2) as well as sudden infant death syndrome (SIDS).
• Protein length: 351 amino acids
• Conjugation: HIS
• Molecular Weight: 40.600kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Most highly expressed in heart tissue, with lower levels in the skeletal muscle, kidney, lung and other organs.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:0.32% Tris HCl, 20% Glycerol, 0.02% DTT
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMAAAPLKVCIVGSGNWGSAVAKIIGNNVKKLQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAMSNLSEAVQDADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIFCKGQVSTATFLESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLLDKFPLFTAVYQICYESRPVQEMLSCLQSHPEHT
• Sequence Similarities: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Gene Information

• Gene Name: GPD1L glycerol-3-phosphate dehydrogenase 1-like [ Homo sapiens ]
• Official Symbol: GPD1L
• Synonyms: GPD1L; glycerol-3-phosphate dehydrogenase 1-like; glycerol-3-phosphate dehydrogenase 1-like protein; KIAA0089
• Gene ID: 23171
• mRNA Refseq: NM_015141
• Protein Refseq: NP_055956
• MIM: 611778
• Uniprot ID: Q8N335
• Chromosome Location: 3p22.3
• Pathway: Glycerophospholipid metabolism, organism-specific biosystem; Glycerophospholipid metabolism, conserved biosystem
• Function: NAD binding; glycerol-3-phosphate dehydrogenase [NAD+] activity; protein homodimerization activity