Recombinant Human GCKR Protein (M1-Q625), His tagged

• Cat.No.: GCKR-1010H
• Product Overview: Recombinant Human 8His-TEV-Glucokinase(M1-Q625 end) Protein was expressed in Insect cell.

Specification

• Description: Regulates glucokinase (GCK) by forming an inactive complex with this enzyme. Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity.
• Source: Insect cell
• Species: Human
• Tag: His
• Form: Liquid
• Protein length: M1-Q625
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: GCKR glucokinase (hexokinase 4) regulator [ Homo sapiens (human) ]
• Official Symbol: GCKR
• Synonyms: GCKR; glucokinase (hexokinase 4) regulator; glucokinase (hexokinase 4) regulatory protein; glucokinase regulatory protein; GKRP; FGQTL5
• Gene ID: 2646
• mRNA Refseq: NM_001486
• Protein Refseq: NP_001477
• MIM: 600842
• UniProt ID: Q14397