GCKR
-
Official Full Name
glucokinase (hexokinase 4) regulator -
Overview
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008] -
Synonyms
GCKR;glucokinase (hexokinase 4) regulator;GKRP;FGQTL5;glucokinase regulatory protein
Recombinant Proteins
- Human
- Rat
- Mouse
- S.cerevisiae
- E.coli
- Mammalian Cell
- HEK293
- Insect Cell
- HEK293T
- Yeast
- S.cerevisiae
- His&SUMO
- His
- Myc&DDK
- His&T7
- Non
- His&Fc&Avi
Involved Pathway
GCKR involved in several pathways and played different roles in them. We selected most pathways GCKR participated on our site, such as Defective TRP may confer susceptibility towards thyroid papillary carcinoma (TPC),Disease,Disorders of transmembrane transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with GCKR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | COX10,AZIN1B,NUDT15,EBP,AS3MT,CYB5A,SLC26A1,NUBP1,SLC26A2,CKMB |
| Hexose transport | SLC5A2,SLC5A9,SLC5A4,SLC2A3 |
| Metabolism of carbohydrates | HPSE,AGL,KHK,SLC25A10,SLC26A1,HS3ST6,SLC35D2,LYVE1,STAB2,UST |
| Disease | PSIP1,AP2S1,OPN1MW,TICAM1,TTR,LRRFIP1,MMAA,RPL35,CCR5,NA |
| Glucose transport | SLC2A3 |
| Disorders of transmembrane transporters | CFTR |
Protein Function
GCKR has several biochemical functions, for example, carbohydrate binding,fructose-6-phosphate binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GCKR itself. We selected most functions GCKR had, and list some proteins which have the same functions with GCKR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbohydrate binding | CLEC1A,CLC,CD209B,CLEC10A,BCAN,SIGLEC8,LGALS9,REG3A,LGALSLB,ILLR4 |
| protein binding | ARMC9,FOXO1,FCHSD2,CBX5,PDK3,LACTB2,PRR3,ARPC2,C2orf65,TMEM120B |
| fructose-6-phosphate binding | PFKFB1,PFKL |
Interacting Protein
GCKR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCKR here. Most of them are supplied by our site. Hope this information will be useful for your research of GCKR.
GCK;CDKN1A
Resources
Related Services
Related Products
References
- Hong, EP; Kim, DH; et al. Interactions of genetic and non-genetic factors on plasma hs-CRP concentration in a Korean community-based cohort study. GENES & GENOMICS 37:231-239(2015).
- Hong, EP; Park, JW; et al. Effect of interactions between genetic polymorphisms and cigarette smoking on plasma triglyceride levels in elderly Koreans: the Hallym Aging Study. GENES & GENOMICS 37:173-181(2015).
