Recombinant Human GAS1, His-tagged

• Cat.No.: GAS1-13160H
• Product Overview: Recombinant Human GAS1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 28-345a.a.
• Description: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: GAS1 growth arrest-specific 1 [ Homo sapiens ]
• Official Symbol: GAS1
• Synonyms: GAS1; growth arrest-specific 1; growth arrest-specific protein 1; Growth arrest specific gene 1; GAS-1; Growth arrest-specific gene-1
• Gene ID: 2619
• mRNA Refseq: NM_002048
• Protein Refseq: NP_002039
• MIM: 139185
• UniProt ID: P54826
• Chromosome Location: 9q21.3-q22
• Pathway: FOXM1 transcription factor network, organism-specific biosystem; Hedgehog Signaling Pathway, organism-specific biosystem; Hedgehog signaling pathway, organism-specific biosystem; Hedgehog signaling pathway, conserved biosystem; Signaling events mediated by the Hedgehog family, organism-specific biosystem
• Function: protein binding