Recombinant Human GABRG2, His-tagged

• Cat.No.: GABRG2-13103H
• Product Overview: Recombinant Human GABRG2 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 40-273a.a.
• Description: This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 [ Homo sapiens ]
• Official Symbol: GABRG2
• Synonyms: GABRG2; gamma-aminobutyric acid (GABA) A receptor, gamma 2; gamma-aminobutyric acid receptor subunit gamma-2; GABA(A) receptor; gamma 2; GABA(A) receptor, gamma 2; GABA(A) receptor subunit gamma-2; CAE2; ECA2; GEFSP3
• Gene ID: 2566
• mRNA Refseq: NM_000816
• Protein Refseq: NP_000807
• MIM: 137164
• UniProt ID: P18507
• Chromosome Location: 5q34
• Pathway: GABA A receptor activation, organism-specific biosystem; GABA receptor activation, organism-specific biosystem; GABAergic synapse, organism-specific biosystem; GABAergic synapse, conserved biosystem; Ion channel transport, organism-specific biosystem; Ligand-gated ion channel transport, organism-specific biosystem; Morphine addiction, organism-specific biosystem
• Function: GABA-A receptor activity; benzodiazepine receptor activity; chloride channel activity; extracellular ligand-gated ion channel activity; ion channel activity; protein binding