Recombinant Human FXYD4, GST-tagged

• Cat.No.: FXYD4-13057H
• Product Overview: Recombinant Human FXYD4 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 1-89a.a.
• Description: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD4, originally named CHIF for channel-inducing factor, has been shown to modulate the properties of the Na,K-ATPase, as has FXYD2, also known as the gamma subunit of the Na,K-ATPase, and FXYD7. Transmembrane topology has been established for FXYD4 and two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Alternatively spliced transcript variants encoding the same protein have been found.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: FXYD4 FXYD domain containing ion transport regulator 4 [ Homo sapiens ]
• Official Symbol: FXYD4
• Synonyms: FXYD domain containing ion transport regulator 4; 4028; Ensembl:ENSG00000150201; FXYD domain-containing ion transport regulator 4;channel-inducing factor; CHIF
• Gene ID: 53828
• mRNA Refseq: NM_001184963.1
• Protein Refseq: NP_001171892.1
• UniProt ID: P59646
• Chromosome Location: 10q11.21
• Pathway: Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem
• Function: ATPase binding; potassium channel activity