Recombinant Human FXR1 protein, His-tagged

• Cat.No.: FXR1-13053H
• Product Overview: Recombinant Human FXR1 protein(1-353 aa), fused with a N-terminal 6*His Tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Form: The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH7.4). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 300mM imidazole.
• Protein length: 1-353 aa
• AA Sequence: MAELTVEVRGSNGAFYKGFIKDVHE DSLTVVFENNWQPERQVPFNEVRLP PPPDIKKEISEGDEVEVYSRANDQE PCGWWLAKVRMMKGEFYVIEYAACD ATYNEIVTFERLRPVNQNKTVKKNT FFKCTVDVPEDLREACANENAHKDF KKAVGACRIFYHPETTQLMILSASE ATVKRVNILSDMHLRSIRTKLMLMS RNEEATKHLECTKQLAAAFHEEFVV REDLMGLAIGTHGSNIQQARKVPGV TAIELDEDTGTFRIYGESADAVKKA RGFLEFVEDFIQVPRNLVGKVIGKN GKVIQEIVDKSGVVRVRIEGDNENK LPREDGMVPFVFVGTKESIGNVQVL LEY
• Purity: 85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
• Storage: Short-term storage: Store at 2-8°C for (1-2 weeks).
  Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, reconstitution with sterile water and addition of an equal volume of glycerol. Avoid repeat freeze-thaw cycles.
• Reconstitution: Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
  After reconstitution with sterile water, if glycerol has no effect on subsequent experiments, it is recommended to add an equal volume of glycerol for long-term storage.

Gene Information

• Gene Name: FXR1 fragile X mental retardation, autosomal homolog 1 [ Homo sapiens ]
• Official Symbol: FXR1
• Synonyms: FXR1; fragile X mental retardation, autosomal homolog 1; fragile X mental retardation syndrome-related protein 1; hFXR1p; FXR1P
• Gene ID: 8087
• mRNA Refseq: NM_001013438
• Protein Refseq: NP_001013456
• MIM: 600819
• UniProt ID: P51114

Reviews

06/08/2023

Highly recommended service, valuable for research projects.

02/08/2022

Exceptional expertise, elevates our research standards.

02/18/2021

Dependable results, a key to research success.

Q&As

What potential therapeutic applications arise from targeting FXR1 in muscular disorders?

Targeting FXR1 could offer therapeutic strategies for treating muscle disorders linked to RNA metabolism abnormalities.

What is the primary role of FXR1 in RNA metabolism?

FXR1, an RNA-binding protein, is involved in regulating RNA metabolism, particularly mRNA processing and turnover.

How does FXR1 interact with other RNA-binding proteins?

FXR1 interacts with a network of RNA-binding proteins, coordinating the regulation of mRNA metabolism.

What role does FXR1 play in protein synthesis?

FXR1 plays a crucial role in modulating protein synthesis by influencing mRNA availability and translation.

How does FXR1 contribute to mRNA stability?

It contributes to mRNA stability, affecting the lifespan and translation efficiency of mRNAs.

What is the impact of altered FXR1 activity on muscle development?

Altered FXR1 activity can affect muscle development and function, potentially leading to muscle-related disorders.

How do genetic variations in FXR1 affect cellular processes?

Genetic mutations in FXR1 can disrupt normal RNA processing and protein synthesis, impacting various cellular functions.