Recombinant Human FUCA1 Protein, GST-tagged

• Cat.No.: FUCA1-4543H
• Product Overview: Human FUCA1 full-length ORF ( AAH17338, 23 a.a. - 461 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Alpha-L-fucosidase (EC 3.2.1.51) is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids (Occhiodoro et al., 1989 [PubMed 2803312]). At least 2 separate polymorphic alpha-L-fucosidases are recognized in man: that in tissues, FUCA1, which is deficient in fucosidosis (MIM 230000), and that in plasma, FUCA2 (MIM 136820).[supplied by OMIM
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 74.03 kDa
• AA Sequence: VRRAQPPRRYTPDWPSLDSRPLPAW FDEAKFGVFIHWGVFSVPAWGSEWF WWHWQGEGRPQYQRFMRDNYPPGFS YADFGPQFTARFFHPEEWADLFQAA GAKYVVLTTKHHEGFTNWPSPVSWN WNSKDVGPHRDLVGELGTALRKRNI RYGLYHSLLEWFHPLYLLDKKNGFK TQHFVSAKTMPELYDLVNSYKPDLI WSDGEWECPDTYWNSTNFLSWLYND SPVKDEVVVNDRWGQNCSCHHGGYY NCEDKFKPQSLPDHKWEMCTSIDKF SWGYRRDMALSDVTEESEIISELVQ TVSLGGNYLLNIGPTKDGLIVPIFQ ERLLAVGKWLSINGEAIYASKPWRV QWEKNTTSVWYTSKGSAVYAIFLHW PENGVLNLESPITTSTTKITMLGIQ GDLKWSTDPDKGLFISLPQLPPSAV PAEFAWTIKLTGVK
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: FUCA1 fucosidase, alpha-L- 1, tissue [ Homo sapiens ]
• Official Symbol: FUCA1
• Synonyms: FUCA1; fucosidase, alpha-L- 1, tissue; tissue alpha-L-fucosidase; alpha-L-fucosidase 1; alpha-L-fucosidase I; alpha-L-fucoside fucohydrolase 1; FUCA
• Gene ID: 2517
• mRNA Refseq: NM_000147
• Protein Refseq: NP_000138
• MIM: 612280
• UniProt ID: P04066

Reviews

08/16/2021

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05/11/2020

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09/12/2019

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Q&As

How do genetic variations in FUCA1 affect its enzymatic activity?

Genetic mutations in FUCA1 can lead to deficient enzyme activity, affecting glycan metabolism.

What is the impact of altered FUCA1 activity on lysosomal storage diseases?

Altered FUCA1 activity is associated with lysosomal storage diseases, such as fucosidosis, due to the accumulation of undigested glycans.

What is the primary role of FUCA1 in cellular metabolism?

FUCA1, an alpha-L-fucosidase, is involved in the breakdown of complex sugars (glycans) in cellular metabolism.

What role does FUCA1 play in lysosomal function?

FUCA1 is crucial for normal lysosomal function, aiding in the breakdown of glycoproteins and glycolipids.

How does FUCA1 contribute to glycan breakdown?

It helps in glycan degradation by cleaving fucose residues, a key step in glycan processing.

How does FUCA1 interact with other enzymes in glycan metabolism?

FUCA1 works alongside other enzymes in glycan metabolism, ensuring efficient breakdown and recycling of cellular components.

What potential therapeutic applications arise from targeting FUCA1 in metabolic disorders?

Targeting FUCA1 could offer therapeutic strategies for treating lysosomal storage disorders and related metabolic conditions.