Recombinant Human FOXP3, MYC/DDK-tagged

• Cat.No.: FOXP3-50H
• Product Overview: Recombinant Human FOXP3 fused with C-terminal MYC/DDK, was expressed in HEK293 Cells.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Molecular Mass: 47.1 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Storage buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Concentration: >50 ug/mL as determined by microplate BCA method
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Storage: Store at -800C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
• OfficialSymbol: FOXP3

Gene Information

• Gene Name: FOXP3 forkhead box P3 [ Homo sapiens ]
• Synonyms: FOXP3; forkhead box P3; JM2; AIID; IPEX; PIDX; XPID; DIETER; forkhead box protein P3; scurfin; FOXP3delta7; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; immune dysregulation, polyendocrinopathy, enteropathy, X-linked
• Gene ID: 50943
• mRNA Refseq: NM_014009
• Protein Refseq: NP_054728
• MIM: 300292
• UniProt ID: Q9BZS1
• Chromosome Location: Xp11.23
• Pathway: Calcineurin-regulated NFAT-dependent transcription in lymphocytes; IL2 signaling events mediated by STAT5
• Function: DNA bending activity; NF-kappaB binding; NFAT protein binding; chromatin binding; double-stranded DNA binding