Recombinant Human fibroblast growth factor 17, His-tagged

• Cat.No.: FGF17-577H
• Product Overview: FGF17, 23-216aa, Human, His tag, E.coli

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 23-216 a.a.
• Description: FGF17 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was shown to be prominently expressed in the cerebellum and cortex. The mouse homolog of this gene was localized to specific sites in the midline structures of the forebrain, the midbrain-hindbrain junction, developing skeleton and developing arteries, which suggests a role in central nervous system, bone and vascular development. Recombinant human FGF17 protein, fused to His-tag at N-terminus, was expressed in E.coli.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
• Molecular Mass: 25.2 kDa (219aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMTQGEN HPSPNFNQYV RDQGAMTDQL SRRQIREYQL YSRTSGKHVQ VTGRRISATA EDGNKFAKLI VETDTFGSRV RIKGAESEKY ICMNKRGKLI GKPSGKSKDC VFTEIVLENN YTAFQNARHE GWFMAFTRQG RPRQASRSRQ NQREAHFIKR LYQGQLPFPN HAEKQKQFEF VGSAPTRRTK RTRRPQPLT
• Purity: >90% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: FGF17 fibroblast growth factor 17 [ Homo sapiens ]
• Official Symbol: FGF17
• Synonyms: FGF17; fibroblast growth factor 17; FGF 13; FGF-17; FGF-13
• Gene ID: 8822
• mRNA Refseq: NM_003867
• Protein Refseq: NP_003858
• MIM: 603725
• UniProt ID: O60258
• Chromosome Location: 8p21.3
• Pathway: Downstream signaling of activated FGFR, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FGFR1 ligand binding and activation, organism-specific biosystem; FGFR1c ligand binding and activation, organism-specific biosystem; FGFR2 ligand binding and activation, organism-specific biosystem; FGFR2c ligand binding and activation, organism-specific biosystem; FGFR3 ligand binding and activation, organism-specific biosystem
• Function: growth factor activity; protein tyrosine kinase activity; type 1 fibroblast growth factor receptor binding; type 2 fibroblast growth factor receptor binding