Recombinant Human Fibroblast Growth Factor 12, His-tagged

• Cat.No.: FGF12-127H
• Product Overview: Recombinant human FGF12 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques,22.6 kDa (201aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: FGF12 (Fibroblast growth factor 12) is a member of the FGF superfamily of molecules which currently stands at 22 members. The FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF12 binds to IB2 (islet brain-2), a cellular kinase scaffold, and voltage gated sodium channels and also plays an important role in intracellular signaling and ion exchange.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MESKEPQLKG IVTRLFSQQG YFLQMHPDGT IDGTKDENSD YTLFNLIPVG LRVVAIQGVK ASLYVAMNGE GYLYSSDVFT PECKFKESVF ENYYVIYSST LYRQQESGRA WFLGLNKEGQ IMKGNRVKKT KPSSHFVPKP IEVCMYREQS LHEIGEKQGR SRKSSGTPTM NGGKVVNQDS T
• Formulation: Liquid in 20mM Tris pH 7.5, 10% glycerol, 1 mM DTT, 2 mM EDTA
• Purity: > 90% by SDS-PAGE
• Concentration: 1 mg/ml (determined by Bradford assay)
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: FGF12 fibroblast growth factor 12 [ Homo sapiens ]
• Synonyms: FGF-12; FGF12B; FHF-1; FHF1; Fibroblast growth factor homologous factor 1; Myocyte-activating factor; fibroblast growth factor 12; fibroblast growth factor 12B; fibroblast growth factor FGF-12b; FGF12
• Gene ID: 2257
• mRNA Refseq: NM_004113
• Protein Refseq: NP_004104
• MIM: 601513
• UniProt ID: P61328
• Chromosome Location: 3q28
• Function: growth factor activity