Recombinant Human FERMT3, His-tagged

• Cat.No.: FERMT3-12846H
• Product Overview: Recombinant Human FERMT3 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• ProteinLength: 321-663a.a.
• Description: Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: FERMT3 fermitin family member 3 [ Homo sapiens ]
• Official Symbol: FERMT3
• Synonyms: fermitin family member 3; 23151; Ensembl:ENSG00000149781; MGC10966; fermitin family homolog 3;kindlin 3;MIG2-like protein;UNC-112 related protein 2;unc-112-related protein 2; URP2; KIND3; MIG-2; MIG2B; URP2SF; UNC112C
• Gene ID: 83706
• mRNA Refseq: NM_031471.5
• Protein Refseq: NP_113659.3
• MIM: 607901
• UniProt ID: Q86UX7
• Chromosome Location: 11q13.1
• Function: integrin binding; phospholipid binding