FERMT3
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Official Full Name
FERMT3 fermitin family member 3 [ Homo sapiens ] -
Overview
Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms. -
Synonyms
fermitin family member 3;23151;Ensembl:ENSG00000149781;MGC10966;fermitin family homolog 3;kindlin 3;MIG2-like protein;UNC-112 related protein 2;unc-112-related protein 2;URP2;KIND3;MIG-2;MIG2B;URP2SF;UNC112C
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FERMT3-12846H | Recombinant Human FERMT3, His-tagged | E.coli | Human | His | 321-663a.a. | |
| FERMT3-6261HCL | Recombinant Human FERMT3 293 Cell Lysate | HEK293 | Human | Non |
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| FERMT3-1223H | Recombinant Human FERMT3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| FERMT3-4077H | Recombinant Human FERMT3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| FERMT3-4787HF | Recombinant Full Length Human FERMT3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 663 amino acids |
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Involved Pathway
FERMT3 involved in several pathways and played different roles in them. We selected most pathways FERMT3 participated on our site, such as Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FERMT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Platelet activation | PIK3R2,MYLK2,VWF,FYN,PLCG2,PTGIR,PPP1CB,GP9,COL27A1,SRC |
Protein Function
FERMT3 has several biochemical functions, for example, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FERMT3 itself. We selected most functions FERMT3 had, and list some proteins which have the same functions with FERMT3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| integrin binding | MFGE8,ADAM25,WISP3,ANGPTL3,CALR,S1PR3,TNN,ITGA5,KDR,FBLN1 |
Interacting Protein
FERMT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FERMT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FERMT3.
VCAM1;LSM8;EXOSC10;ugpC;TINF2;UHRF1BP1L;ZC3H18;h0y2u5_human;EIF4E2;PDCD6;SNRNP200;MYC;FN1;COX5A;PRDX5;STXBP1;PRDX1
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References
- Huet-Calderwood, C; Brahme, NN; et al. Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activation. JOURNAL OF CELL SCIENCE 127:4308-4321(2014).
- Suratannon, N; Chatchatee, P; et al. Adaptive Immune defect in a rare phagocytic disorder: leukocyte adhesion deficiency III with a novel missense mutation in FERMT3. ALLERGY 69:500-500(2014).
