Recombinant Human FCAR Protein, His-tagged

• Cat.No.: FCAR-213H
• Product Overview: Recombinant Human FCAR(22-227aa) fused with His tag at C-terminal was expressed in Insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Protein Length: 22-227aa
• Description: FCAR, also known as immunoglobulin alpha Fc receptor isoform, is a member of the multichain immune recognition receptor family which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. It plays a role in both pro- and anti-inflammatory responses depending on the state of IgA bound. It is also an important Fc receptor for neutrophil killing of tumor cells. When FCAR expressing neutrophils come into contact with IgA-opsonized tumor cells, the neutrophils not only perform antibody-dependent cell-mediated cytotoxicity, but also release the cytokines TNF-alpha and IL-1beta which cause increased neutrophil migration to the site.
• Form: Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
• Molecular Mass: 24.5kDa (215aa) 28-40kDa (SDS-PAGE under reducing conditions)
• AA Sequence: ADPQEGDFPM PFISAKSSPV IPLDGSVKIQ CQAIREAYLT QLMIIKNSTY REIGRRLKFW NETDPEFVID HMDANKAGRY QCQYRIGHYR
  FRYSDTLELV VTGLYGKPFL SADRGLVLMP GENISLTCSS AHIPFDRFSL AKEGELSLPQ HQSGEHPANF SLGPVDLNVS GIYRCYGWYN
  RSPYLWSFPS NALELVVTDS IHQDYTTQNH HHHHH
• Purity: > 85% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25mg/ml (determined by Absorbance at 280nm)

Gene Information

• Gene Name: FCAR Fc fragment of IgA, receptor for [ Homo sapiens ]
• Official Symbol: FCAR
• Synonyms: FCAR; Fc fragment of IgA, receptor for; immunoglobulin alpha Fc receptor; CD89; IgA Fc receptor; Fc alpha receptor
• Gene ID: 2204
• mRNA Refseq: NM_002000
• Protein Refseq: NP_001991
• MIM: 147045
• UniProt ID: P24071