Recombinant Human eukaryotic translation initiation factor 4B Protein, His tagged

• Cat.No.: EIF4B-204H
• Product Overview: Recombinant human ANXA6 protein (P23588-1) (Met 1-Asp673) with a His tag at the C-terminus was expressed in E. coli.

Specification

• Description: Enables RNA binding activity. Predicted to be involved in eukaryotic translation initiation factor 4F complex assembly and formation of translation preinitiation complex. Located in cytosol. Biomarker of autism spectrum disorder and major depressive disorder. Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
• Source: E. coli
• Species: Human
• Tag: C-His
• Protein length: 395-611aa
• Molecular Mass: 25.5 kDa
• Endotoxin: Less than 1.0 EU/μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
• Reconstitution: Reconstitute at 250 μg/mL in sterile water.

Gene Information

• Gene Name: EIF4B eukaryotic translation initiation factor 4B [ Homo sapiens (human) ]
• Official Symbol: EIF4B
• Synonyms: EIF4B; eukaryotic translation initiation factor 4B; EIF-4B; PRO1843
• Gene ID: 1975
• mRNA Refseq: NM_001417
• Protein Refseq: NP_001408
• MIM: 603928
• UniProt ID: P23588