EIF4B
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Official Full Name
eukaryotic translation initiation factor 4B -
Synonyms
EIF4B;eukaryotic translation initiation factor 4B;EIF-4B;PRO1843
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293T
- In Vitro Cell Free System
- E. coli
- HEK293
- Mammalian cells
- GST
- Non
- His
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
EIF4B involved in several pathways and played different roles in them. We selected most pathways EIF4B participated on our site, such as Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,Cap-dependent Translation Initiation,Deadenylation of mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GTP hydrolysis and joining of the 60S ribosomal subunit | EIF2S1,EIF1AX,EIF2S1A,EIF5,EIF4A1,EIF3K,EIF4A2,EIF4H,EIF1AXA,EIF2S3 |
| IGF1R signaling cascade | RRAGB,HBXIP,C7orf59,RRAGA,IGF2B,LAMTOR1 |
| Cap-dependent Translation Initiation | EIF4E,EIF4A2,EIF4EB,EIF4H,EIF2S1A,EIF4EBP1,EIF2S3,EIF1AX,EIF1AXA,FAUB |
| Deadenylation of mRNA | EIF4G1,EIF4EB,TNKS1BP1,EIF4E,EIF4A2,D1BWG0212E,EIF4A1,PAIP1,C2orf29 |
| Deadenylation-dependent mRNA decay | D1BWG0212E,EIF4G1,DCP2,EIF4EB,PAIP1,EIF4A1,C2orf29,EIF4E,DDX6,LSM6 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | EIF4EB,EIF1AX,EIF4A2,EIF4EBP1,EIF2S1A,FAUB,EIF4A1,EIF2S3,EIF2S1,EIF4H |
| Eukaryotic Translation Initiation | EIF1AXA,EIF4A1,EIF3K,FAUB,EIF1AX,EIF2S1,EIF2S3,EIF5,EIF2B1,EIF4G1 |
| Gene Expression | SAP30,ELAC2,ZNF287,ZNF143,ZNF561,SNUPN,AIMP2,ZNF274,DNAJC8,NR1I3 |
Protein Function
EIF4B has several biochemical functions, for example, RNA binding,nucleotide binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4B itself. We selected most functions EIF4B had, and list some proteins which have the same functions with EIF4B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleotide binding | NT5C3A,CELF5A,ACSL1,HNRNPM,HNRNPAB,RBFOX2,RAB12,RBM15B,RAB11BB,KIAA0430 |
| poly(A) RNA binding | RPL18A,PARP1,HDLBP,RPP25,HIST1H1C,DCN,EIF3G,GLTSCR2,CDC42EP4,MRPS24 |
| protein binding | COPB1,RIMS1,RBM11,LOXL4,NEUROD1,DBF4B,GAN,OAZ3,C14orf166,CDK10 |
| translation initiation factor activity | GTPBP1L,GTPBP2,EIF3JB,EIF5,DHX29,EIF3E,EIF2S3,DENR,MTIF3,AGO2 |
| RNA binding | RTCA,EIF2S1A,RBMS3,METTL3,PABPC1A,TIAL1,ATXN1L,RPLP1,PABPN1,TTC6 |
Interacting Protein
EIF4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4B here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4B.
EIF3A;TINF2;npm_alk;PLK1;CSNK2A1;CAMK2D;RPS6KA1;EIF3H;USP11;Ccdc15;KBTBD7;NELL1
EIF4B Related Signal Pathway
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References
- Osman, AM; van Loveren, H; et al. The immunosuppressant tributyltin oxide blocks the mTOR pathway, like rapamycin, albeit by a different mechanism. JOURNAL OF APPLIED TOXICOLOGY 34:1361-1367(2014).
- Hernandez, G; Lalioti, V; et al. Identification and characterization of the expression of the translation initiation factor 4A (eIF4A) from Drosophila melanogaster. PROTEOMICS 4:316-326(2004).
- von der Haar, T; McCarthy, JEG; et al. Intracellular translation initiation factor levels in Saccharomyces cerevisiae and their role in cap-complex function. MOLECULAR MICROBIOLOGY 46:531-544(2002).
- Metz, AM; Wong, KCH; et al. Eukaryotic initiation factor 4B from wheat and Arabidopsis thaliana is a member of a multigene family. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 266:314-321(1999).
