Recombinant Human ETF1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: ETF1-3650H
• Product Overview: ETF1 MS Standard C13 and N15-labeled recombinant protein (NP_004721) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 48.9 kDa
• AA Sequence: MADDPSAADRNVEIWKIKKLIKSLE AARGNGTSMISLIIPPKDQISRVAK MLADEFGTASNIKSRVNRLSVLGAI TSVQQRLKLYNKVPPNGLVVYCGTI VTEEGKEKKVNIDFEPFKPINTSLY LCDNKFHTEALTALLSDDSKFGFIV IDGSGALFGTLQGNTREVLHKFTVD LPKKHGRGGQSALRFARLRMEKRHN YVRKVAETAVQLFISGDKVNVAGLV LAGSADFKTELSQSDMFDQRLQSKV LKLVDISYGGENGFNQAIELSTEVL SNVKFIQEKKLIGRYFDEISQDTGK YCFGVEDTLKALEMGAVEILIVYEN LDIMRYVLHCQGTEEEKILYLTPEQ EKDKSHFTDKETGQEHELIESMPLL EWFANNYKKFGATLEIVTDKSQEGS QFVKGFGGIGGILRYRVDFQGMEYQ GGDDEFFDLDDYTRTRPLEQKLISE EDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: ETF1 eukaryotic translation termination factor 1 [ Homo sapiens (human) ]
• Official Symbol: ETF1
• Synonyms: ETF1; eukaryotic translation termination factor 1; ERF, ERF1, SUP45L1; eukaryotic peptide chain release factor subunit 1; eRF1; polypeptide chain release factor 1; RF1; sup45 (yeast omnipotent suppressor 45) homolog like 1; TB3 1; protein Cl1; eukaryotic release factor 1; sup45 (yeast omnipotent suppressor 45) homolog-like 1; ERF; ERF1; TB3-1; D5S1995; SUP45L1; MGC111066
• Gene ID: 2107
• mRNA Refseq: NM_004730
• Protein Refseq: NP_004721
• MIM: 600285
• UniProt ID: P62495

Reviews

11/25/2022

What sets this protein apart is the outstanding technical support provided by the manufacturer.

09/20/2022

Its versatility allows me to explore its diverse roles in various biochemical and biological processes accurately.

07/18/2019

The ETF1 Protein is of exceptional quality and is precisely tailored to meet my experimental requirements.

Q&As

Are there any ongoing clinical trials related to ETF1 protein disorders?

There may be clinical trials evaluating potential treatments or interventions for ETF1 protein disorders, and individuals and families affected by these disorders can consider participating in such trials.

What are the symptoms of metabolic disorders caused by ETF1 protein dysfunction?

Symptoms may include muscle weakness, lethargy, hypoglycemia, metabolic acidosis, and in some cases, developmental delays and neurological symptoms.

Can ETF1 protein disorders be detected before birth?

Yes, prenatal testing through genetic screening can detect mutations in the ETF1 gene, allowing for early intervention and management.

How are ETF1 protein disorders diagnosed?

Diagnosis typically involves biochemical testing, genetic testing, and metabolic screening to identify abnormalities in fatty acid metabolism.

Can ETF1 protein disorders affect individuals of all ages?

Yes, ETF1 protein disorders can affect individuals of all ages, from newborns to adults, and may present with different symptoms at different stages of life.