Recombinant Human ESX1, His-tagged

• Cat.No.: ESX1-12563H
• Product Overview: Recombinant Human ESX1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• ProteinLength: 1-406a.a.
• Description: This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: ESX1 ESX homeobox 1 [ Homo sapiens ]
• Official Symbol: ESX1
• Synonyms: ESX1; ESX homeobox 1; ESX1L, extraembryonic, spermatogenesis, homeobox 1 homolog (mouse); homeobox protein ESX1; ESXR1; ESX1-related protein; extraembryonic, spermatogenesis, homeobox 1 homolog; ESX1L
• Gene ID: 80712
• mRNA Refseq: NM_153448
• Protein Refseq: NP_703149
• MIM: 300154
• UniProt ID: Q8N693
• Chromosome Location: Xq22.2
• Function: sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity