Recombinant Human ERN1 Protein, His-tagged

Cat.No. : ERN1-1490H
Product Overview : Recombinant Human ERN1 Protein (Phe571~Phe832) was expressed in E. coli with N-terminal His Tag.
Availability March 14, 2025
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Species : Human
Source : E.coli
Tag : His
Protein Length : 571-832 a.a.
Description : This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1.
Form : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Molecular Mass : 33.3kDa
Purity : > 97%
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Gene Name ERN1 endoplasmic reticulum to nucleus signaling 1 [ Homo sapiens (human) ]
Official Symbol ERN1
Synonyms IRE1; IRE1P; IRE1a; hIRE1p
Gene ID 2081
mRNA Refseq NM_001433.4
Protein Refseq NP_001424.3
MIM 604033
UniProt ID O75460

Not For Human Consumption!

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