Recombinant Human ERCC2 Protein

• Cat.No.: ERCC2-13H
• Product Overview: Recombinant Human ERCC2 Protein was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Description: The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Form: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl.
• Molecular Mass: ~26.3 kDa
• AA Sequence: DGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQQL
• Purity: >90%
• Storage: Short Term Storage at 4 centigrade, Long Term, please prepare aliquots with 20% glycerol and store at -20 to -80 centigrade. Avoid freeze/thaw cycles.
• Concentration: 0.12 mg/ml
• Official Full Name: ERCC excision repair 2, TFIIH core complex helicase subunit

Gene Information

• Gene Name: ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit [ Homo sapiens (human) ]
• Official Symbol: ERCC2
• Synonyms: EM9; TTD; XPD; TTD1; COFS2; TFIIH
• Gene ID: 2068
• mRNA Refseq: NM_000400
• Protein Refseq: NP_000391
• MIM: 126340
• UniProt ID: P18074