ERCC2
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Official Full Name
excision repair cross-complementing rodent repair deficiency, complementation group 2 -
Overview
The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ERCC2;excision repair cross-complementing rodent repair deficiency, complementation group 2;xeroderma pigmentosum complementary group D , XPD;TFIIH basal transcription factor complex helicase XPD subunit;EM9;excision repair cross complementing rodent
Recombinant Proteins
- Zebrafish
- Human
- Mouse
- Mammalian Cells
- E.coli
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ERCC2-11166Z | Recombinant Zebrafish ERCC2 | Mammalian Cells | Zebrafish | His |
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| ERCC2-30131TH | Recombinant Human ERCC2, His-tagged | E.coli | Human | His | 533-760 a.a. |
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| ERCC2-3457H | Recombinant Human ERCC2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| ERCC2-5285M | Recombinant Mouse ERCC2 Protein | Mammalian Cells | Mouse | His |
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| ERCC2-6566HCL | Recombinant Human ERCC2 293 Cell Lysate | HEK293 | Human | Non |
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| ERCC2-13H | Recombinant Human ERCC2 Protein | E.coli | Human |
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| ERCC2-2397H | Recombinant Human ERCC2 Protein (Ala404-Leu637), N-His tagged | E.coli | Human | His | Ala404-Leu637 |
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| ERCC2-2842M | Recombinant Mouse ERCC2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| ERCC2-2842M-B | Recombinant Mouse ERCC2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| ERCC2-4548HF | Recombinant Full Length Human ERCC2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 405 amino acids |
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Involved Pathway
ERCC2 involved in several pathways and played different roles in them. We selected most pathways ERCC2 participated on our site, such as Basal transcription factors,Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Basal transcription factors | CCNH,GTF2H4,GTF2B,GTF2IRD1,TAF2,CDK7,TBPL2,TAF9,GTF2F2A,GTF2H2C_2 |
| Nucleotide Excision Repair | PPIE,GTF2H4,COPS6,INO80B,GTF2H5,XPA,INO80,KIAA1530,ERCC5,ACTR5 |
Protein Function
ERCC2 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding,5-3 DNA helicase activity,ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC2 itself. We selected most functions ERCC2 had, and list some proteins which have the same functions with ERCC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ARXA,PUF60,ZKSCAN6,HOXB9A,SMARCC1,TOP2A,ZFP518A,SOS1,POLR2K,ZNF317 |
| ATP-dependent DNA helicase activity | BLM,RECQL,CHD4,ERCC3,DHX9,FBXO18,BRIP1,RTEL1,CHD2,CHST13 |
| contributes_to RNA polymerase II carboxy-terminal domain kinase activity | GTF2H3,GTF2H4,GTF2H2,ERCC3,MNAT1,GTF2H1 |
| protein C-terminus binding | PHB,ERCC4,CSK,YWHAQ,RAD51,KSR1,DDX1,TCF4,MKI67,PIAS4 |
| 4 iron, 4 sulfur cluster binding | BRIP1,NTHL1,DEM1,ACO2,TYW1B,PRIM2,SDHB,NUBPL,TYW1,DDX11 |
| contributes_to DNA-dependent ATPase activity | MNAT1,BPTF,GTF2H3,GTF2H2,GTF2H4,RBBP4,GTF2H1,ERCC3 |
| metal ion binding | BCKDHA,MYLIPA,MECOM,RNF220A,RAB11FIP3,CHN2,CBFA2T2,ZBTB20,ADH1,FGD2 |
| contributes_to protein kinase activity | ERCC3,GTF2H4,GTF2H2,GTF2H3,GTF2H1 |
| DNA-dependent ATPase activity | XRCC2,IGHMBP2,TTF2,MSH2,DHX36,CHD8,SMARCA2,RAD51D,XRCC3,RAD51L3 |
Interacting Protein
ERCC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC2.
GTF2H2C;b4dyc6_human;STIP1;HSF2;HSP90AB1;NUDCD3;q96be0_human;PPP5C;AARSD1;CACYBP;EGFR;CDK7;GTF2H5
Resources
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References
- Yu, M; Bell, RH; et al. Deficiency in Nucleotide Excision Repair Family Gene Activity, Especially ERCC3, Is Associated with Non-Pigmented Hair Fiber Growth. PLOS ONE 7:-(2012).
- Capella, G; Pera, G; et al. DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 37:1316-1325(2008).
