Recombinant Human EPH Receptor B4, His-tagged

• Cat.No.: EPHB4-4762H
• Product Overview: Recombinant human EPHB4 contains C-terminal polyhistidine tag and has a calculated MW of 57.8 kDa. As a result of glycosylation, DTT-reduced protein migrates as 65-70 kDa polypeptide in SDS-PAGE.

Specification

• Cat. No.: EPHB4-4762H
• Description: Ephrin type-B receptor 4 (EPHB4),is a member of Eph family. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase(RTK) family. The protein encoded by EPHB4 binds to Ephrin-B2 and plays an essential role in vascular development.
• Source: Recombinant human EPHB4 Glu17-Ala539 (Accession NM_004435) was produced in human HEK293 cells
• Species: Human
• Form: Bulk protein in a 0.22 μm filtered solution of PBS, pH 7.4 and delivered as liquid formulation or lyophilized powder. Normally 5-8% trehalose and mannitol are added as protectants before mannitol are added as protectants before lyophilization.
• Purity: >97% as determined by SDS-PAGE. All lots are greater than 97% pure.
• Endotoxin: Less than 1.0 EU per 1 μg of the human EPHB4 by the LAL method.
• Storage: Stable in lyophilized state at 4°C for 1 year after receipt. Sterile stock solutions reconstituted are stable at 4°C for 2 months and at -20°C for 6 months. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: EPHB4 EPH receptor B4 [ Homo sapiens ]
• Official Symbol: EPHB4
• Synonyms: EPHB4; EPH receptor B4; HTK; MYK1; TYRO11; ephrin receptor EphB4; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; hepatoma transmembrane kinase; EC 2.7.10.1; Tyro11; Ephrin type-B receptor 4; Tyrosine-protein kinase receptor HTK; Tyrosine-protein kinase TYRO11; EPH receptor B4; Tyrosine-protein kinase receptor HTK; ephrin receptor EphB4; hepatoma transmembrane kinase
• Gene ID: 2050
• mRNA Refseq: NM_004444
• Protein Refseq: NP_004435
• MIM: 600011
• UniProt ID: P54760
• Chromosome Location: 7q22
• Pathway: Axon guidance
• Function: ATP binding; ephrin receptor activity; nucleotide binding; protein binding; receptor activity; transferase activity