Recombinant Human EPH Receptor B3, GST-tagged

• Cat.No.: EPHB3-1214H
• Product Overview: Recombinant humanEPHB3 catalytic domain (aa 623-907) with GST tag containing additionalC-terminal amino acids KGGRADPAFLYKVV. Activated in vitro via auto-phosphorylation.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Protein Length: 623-907 a.a.
• Description: EPHB3 is a protein that in humans is encoded by theEPHB3 gene. Ephrin receptors and their ligands,the ephrins, mediate numerous developmental processes, particularly in thenervous system. Based on their structures and sequence relationships, ephrinsare divided into the ephrin-A (EFNA) class, which are anchored to themembrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB)class, which are transmembrane proteins.
• Form: Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT +50% glycerol.
• Molecular Weight: 61.9 kDa
• Concentration: 0.35 mg/ml
• Purity: ≥ 90% as determinedby SDS-PAGE analysis.
• Specific Activity: 580 nmole ofphosphate transferred to poly [Glu,Tyr] 4:1 substrate per minute per mg of totalprotein at 30°C.Activity determined at a final protein concentration of 2 μg/ml.
• Storage: Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: EPHB3

Gene Information

• Gene Name: EPHB3 EPH receptor B3 [ Homosapiens ]
• Synonyms: EPHB3; EPH receptorB3; ETK2;HEK2; TYRO6; ephrin type-B receptor 3; EK2; EPH-like kinase 2; OTTHUMP00000210455;embryonic kinase 2; human embryo kinase 2; EPH-like tyrosine kinase 2; EPH-liketyrosine kinase-2; tyrosine-protein kinase TYRO6
• Gene ID: 2049
• mRNA Refseq: NM_004443
• Protein Refseq: NP_004434
• MIM: 601839
• UniProt ID: P54753
• Chromosome Location: 3q21-qter
• Pathway: Axon guidance; EPHBforward signaling; EphrinB-EPHB pathway
• Function: ATP binding; axonguidance receptor activity; ephrin receptor activity; nucleotide binding;receptor activity